what is the Atlas about ?
MAPPING THE ELECTRICAL LANGUAGE OF LIFE
The Bioelectric Atlas (BEA) is a collaborative initiative to decode, visualize, and apply the patterns of bioelectric signaling across biological systems.
core objectives:
Reveal the Bioelectric Landscape
Support Predictive Modeling & Design
Reveal the Bioelectric Landscape
Systematically map voltage patterns, ionic gradients, and bioelectric domains across tissues and organisms.
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Enable Bioelectronic Integration
Support Predictive Modeling & Design
Reveal the Bioelectric Landscape
Provide a reference framework for designing responsive genetic circuits, biosensors, and regenerative interfaces.
Cross-Disciplinary Collaboration
Support Predictive Modeling & Design
Support Predictive Modeling & Design
Bridge synthetic biology, neurobiology, bioengineering, and regenerative medicine through shared access and tools.
Support Predictive Modeling & Design
Support Predictive Modeling & Design
Support Predictive Modeling & Design
Inform computational models of tissue development and support hypothesis-driven design of interventions.
The Bioelectric Atlas - Key Points
1. Electricity as a Biological Language
Every cell in your body carries an electrical charge — not just neurons. The bioelectric hypothesis suggests that this electrical activity helps organize how cells grow, move, and heal. It’s like a hidden language that guides development and regeneration — a biological "circuit board."
2. Signals That Shape Life
From flatworms that regrow heads with altered electrical signals to human tissues displaying voltage shifts during healing, scientific evidence is mounting: bioelectric signals don’t just mirror life — they help shape it. These signals influence where organs form, how wounds close, and how tissues regenerate.
3. A Shared Map for Many Disciplines
The Bioelectric Atlas project is an open-access, high-resolution mapping project designed to chart the spatial and temporal dynamics of bioelectric activity in living systems. By integrating data from tools like voltage-sensitive imaging, optogenetics, and ion channel profiling, the Atlas provides a common platform for collaboration across fields — from developmental biology and neuroscience to synthetic bioelectronics and regenerative medicine.
4. A Platform for Discovery and Connection
The Bioelectric Atlas is more than a map — it's a multi-modal reference built to reveal how bioelectric states shape cellular behavior, tissue formation, and functional dynamics. Designed to support both fundamental research and real-world applications, the project invites experts working at the interface of biology and engineering to connect, contribute, and collaborate. It is built on the belief that sharing this information openly can accelerate innovation across medicine, synthetic biology, and bioelectronic design.
Examples for Next-Generation Biotech Innovation
Grow one, two, or zero heads (Morphogenesis)
Grow one, two, or zero heads (Morphogenesis)
Grow one, two, or zero heads (Morphogenesis)
When altering their bioelectric patterns of Flatworms, they'll regrow one, two, or zero heads
Regeneration
Grow one, two, or zero heads (Morphogenesis)
Grow one, two, or zero heads (Morphogenesis)
bioreactor was used to trigger long-term regrowth of functional frog limbs by activating natural regenerative pathways — including bioelectric signaling that guides tissue patterning and growth. (https://pubmed.ncbi.nlm.nih.gov/35080969/)
Changing from Tail to an Eye
Grow one, two, or zero heads (Morphogenesis)
Changing from Tail to an Eye
When this frog was a tadpole, researchers implanted the cells necessary to grow an eye on its tail. As it grew and its tale shrunk, the eye persisted—as did it'sability to see. (https://pubmed.ncbi.nlm.nih.gov/22159581/ )
Table of Suggested Articles
THE ASSOCIATION OF BIOELECTRIC SIGNALING
Mission Statement
The Israeli Association for Bioelectric Signalling is dedicated to advancing research, collaboration, and application of bioelectric signalling as a fundamental biological system. By fostering multidisciplinary partnerships, the association seeks to map, model, and harness bioelectricity for breakthroughs in regeneration, development, cognition, and biotechnology.
Aims
- Create a centralized community of researchers working on bioelectric signalling and bioelectric-based interventions.
- Develop the Bioelectric Atlas, a comprehensive mapping of bioelectric patterns across cell types.
- Attract research funding by establishing an international scientific and commercial framework.
- Advance Israel’s leadership in bioelectricity as a key driver of biological function and innovation.
- Promote interdisciplinary research, bridging bioengineering, regenerative medicine, and computational biology.
Objectives
- Identify and bring together leading research groups in Israel working on bioelectricity to validate the concept, science and disability.
- Establish international collaborations with leading institutions (e.g., Levin Lab, Tufts University).
- Secure government and private sector funding for foundational research and applications.
- Develop computational tools & machine learning frameworks for bioelectric signal analysis.
- Promote publications, workshops, and conferences to expand knowledge and engagement.
- develop a standardized bioelectric reference model by mapping and defining "NORMAL" bioelectric behaviour of cells across specific functions and lifecycle
- Set up pilot studies to validate bioelectric-based regenerative medicine approaches.